Product Information
- 1H-Purine-2,8(3H,7H)-dione, 6-amino-
- 2,8-Dihydroxyadenine
- 2,8-Dioxyadenine
- 2H-Purine-2,8(3H)-dione, 6-amino-7,9-dihydro-
- 6-Amino-2,8-dihydroxypurine
- 6-Amino-7,9-dihydro-2H-purine-2,8(3H)-dione
- 6-amino-1H-purine-2,8(7H,9H)-dione
- Purine-2,8-diol, 6-amino-
6-Amino-1H-purine-2,8(3H,7H)-dione is a nucleoside analogue that inhibits bacterial growth by binding to the DNA-dependent RNA polymerase. This leads to transcriptional arrest and subsequent cell death. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. 6-Amino-1H-purine-2,8(3H,7H)-dione is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. This active form is also used as a diagnostic agent for bacterial infections.
Chemical properties
Technical inquiry about: 3D-FA159663 6-Amino-1H-purine-2,8(3H,7H)-dione
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