3-Amino-6-phenylpyridazine

CAS: 14966-91-7

Ref. 3D-FA170404

Product Information

• Name: 3-Amino-6-phenylpyridazine
• Synonyms: 6-Phenyl-pyridazin-3-ylamine, Timtec-Bb Sbb005608, 6-Phenyl-3-pyridazinamine, 6-Phenylpyridazin-3-Amine

Description

3-Amino-6-phenylpyridazine (3AP) is a synthetic compound that induces apoptosis in cancer cells. 3AP activates caspase 1, the initiator caspase of the apoptotic pathway. It binds to the kinase domain of dapk1, which is a pro-apoptotic protein, and causes its activation. This leads to an increase in pro-apoptotic proteins such as Bax and Bak, which then translocate to mitochondria and trigger cytochrome C release. 3AP also inhibits tyrosine phosphatases and prevents the inhibition of phosphorylation of pro-apoptotic proteins by these enzymes. 3AP has been shown to induce cell death in certain cancer cells without affecting normal cells, making it a potential drug target for cancer therapy.

• Brand: Biosynth

Chemical properties

• Molecular weight: 171.2 g/mol
• Formula: C₁₀H₉N₃
• Purity: Min. 95%
• InChI: InChI=1S/C10H9N3/c11-10-7-6-9(12-13-10)8-4-2-1-3-5-8/h1-7H,(H2,11,13)
• InChI key: InChIKey=YTDZFWNQRRMELI-UHFFFAOYSA-N
• SMILES: Nc1ccc(-c2ccccc2)nn1