5-Amino-2-chlorobenzotrifluoride

CAS: 320-51-4

Ref. 3D-FA17449

Product Information

• Name: 5-Amino-2-chlorobenzotrifluoride
• Synonyms: 4-Chloro-3-(trifluoromethyl)-benzenamine4-chloro-a,a,a-trifluoro-m-toluidine(4-Chloro-3-trifluoromethylphenyl)amine, (4-Chloro-3-trifluoromethylphenyl)amine, 1,4-Dichloro-2,5-Bis(Trifluoromethyl)Benzene, 2-Chloro-5-Aminobenzotrifluoride, 3-(Trifluoromethyl)-4-chloroaniline, 3-Amino-6-chlorobenzotrifluoride, 3-Trifluoromethyl-4-chlorophenylamine, 4-Chloro-3-(trifluoromethyl)-benzenamine, 4-Chloro-3-(trifluoromethyl)aniline, 4-Chloro-3-Trifluoromethylaniline, 4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine, 4-Chloro-α,α,α-trifluoro-m-toluidine, 5-Amino-2-chlorobenzo trifluoride, 5-Amino-2-chlorotrifluorotoluene, Benzenamine, 4-chloro-3-(trifluoromethyl)-, NSC 61405, m-Toluidine, 4-chloro-α,α,α-trifluoro-

Description

5-Amino-2-chlorobenzotrifluoride (5ACBF) is an anti-cancer drug that inhibits the growth of cancer cells by binding to actin filaments and inhibiting the production of proteins essential for cell division. It is used to treat lung cancer, colorectal cancer, prostate cancer, and hematopoietic malignancies. 5ACBF also has a variety of side effects that may be due to its potent inhibitory effect on actin polymerization. These side effects include chronic cough, abdominal surgery, and increased susceptibility to infectious diseases. 5ACBF has been shown to have some clinical efficacy against colorectal cancer in combination with sorafenib in clinical trials conducted on patients with advanced disease. The therapeutic index for 5ACBF is high as it does not cross the blood brain barrier and does not accumulate in most tissues (except the lungs).

• Brand: Biosynth

Chemical properties

• Molecular weight: 195.57 g/mol
• Formula: C₇H₅ClF₃N
• Purity: Min. 95%
• InChI: InChI=1S/C7H5ClF3N/c8-6-2-1-4(12)3-5(6)7(9,10)11/h1-3H,12H2
• InChI key: InChIKey=ASPDJZINBYYZRU-UHFFFAOYSA-N
• SMILES: Nc1ccc(Cl)c(C(F)(F)F)c1