2-Amino-3-methyl-3H-imidazo[4,5-f]quinoline

CAS: 76180-96-6

Ref. 3D-FA17532

Product Information

• Name: 2-Amino-3-methyl-3H-imidazo[4,5-f]quinoline
• Synonyms: 3-Methyl-3H-imidazo[4,5-f]quinolin-2-amineIQ, 2-Amino-3-methylimidazo(4,5-f)quinoline, 3-Methyl-3H-imidazo(4,5-f)quinolin-2-amine, 3-methyl-3H-imidazo[4,5-f]quinolin-2-amine hydrobromide (1:1), 3H-Imidazo(4,5-f)quinolin-2-amine, 3-methyl-, 3H-Imidazo(4,5-f)quinoline, 2-amino-3-methyl-, Brn 5014055, Ccris 1767, Hsdb 7085, IQ, N3-Iq

Description

2-Amino-3-methyl-3H-imidazo[4,5-f]quinoline (IQ) is a genotoxic agent that can cause DNA damage and cell death in mammalian cells. IQ is metabolized by cytochrome P450 enzymes to reactive metabolites that bind to DNA and inhibit topoisomerase II. This leads to the formation of bulky adducts in the DNA and ultimately causes cell death. IQ has been shown to be carcinogenic in mice, as it induced liver lesions and t-cell lymphomas. The drug has also been used as a model system for the study of carcinogenesis caused by 2-amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP).

• Brand: Biosynth

Chemical properties

• Molecular weight: 198.22 g/mol
• Formula: C₁₁H₁₀N₄
• Purity: Min. 95%
• Color/Form: Green Powder
• InChI: InChI=1S/C11H10N4/c1-15-9-5-4-8-7(3-2-6-13-8)10(9)14-11(15)12/h2-6H,1H3,(H2,12,14)
• InChI key: InChIKey=ARZWATDYIYAUTA-UHFFFAOYSA-N
• SMILES: Cn1c(N)nc2c3cccnc3ccc21