N-(2-Aminoethyl)-5-isoquinolinesulfonamide

CAS: 84468-17-7

Ref. 3D-FA17737

Product Information

• Name: N-(2-Aminoethyl)-5-isoquinolinesulfonamide
• Synonyms: Isoquinoline-5-sulfonic acid N-(2-aminoethyl)amideN-(2-Aminoethyl)-5-isoquinolinesulfonic acid amide, Aeiqs, H-9, H9, Protein kinase C inhibitor H-9, 5-Isoquinolinesulfonamide, N-(2-aminoethyl)-, N-(2-aminoethyl)isoquinoline-5-sulfonamide, 5-[(2-Ammonioethyl)Sulfamoyl]Isoquinolinium Dichloride, 2-[(Isoquinolin-5-Ylsulfonyl)Amino]Ethanaminium

Description

N-(2-Aminoethyl)-5-isoquinolinesulfonamide is a cyclic peptide that binds to the alpha subunit of guanine nucleotide regulatory protein (G protein). It is used as an immunosuppressant in the treatment of autoimmune diseases. N-(2-Aminoethyl)-5-isoquinolinesulfonamide inhibits the production of nitric oxide, which has been shown to contribute to the development of congestive heart failure and infectious diseases. This drug also has a depressant effect on neurons in the cerebellar granule layer.

N-(2-Aminoethyl)-5-isoquinolinesulfonamide binds to G protein by competitive inhibition, which prevents its interaction with other proteins and thus blocks signal transduction from G protein to adenylate cyclase. The binding site for this drug is located at the interface between alpha and beta subunits of G protein. This drug also inhibits

• Brand: Biosynth

Chemical properties

• Molecular weight: 251.31 g/mol
• Formula: C₁₁H₁₃N₃O₂S
• Purity: Min. 95%
• InChI: InChI=1S/C11H13N3O2S/c12-5-7-14-17(15,16)11-3-1-2-9-8-13-6-4-10(9)11/h1-4,6,8,14H,5,7,12H2
• InChI key: InChIKey=DCVZSHVZGVWQKV-UHFFFAOYSA-N
• SMILES: NCCNS(=O)(=O)c1cccc2cnccc12