Amonafide

CAS: 69408-81-7

Ref. 3D-FA17880

Product Information

• Name: Amonafide
• Synonyms: 5-Amino-2-[2-(dimethylamino)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dioneFA 142M-FA 142, 1H-Benz[de]isoquinoline-1,3(2H)-dione, 5-amino-2-[2-(dimethylamino)ethyl]-, 5-Amino-2-[2-(dimethylamino)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione, 5-amino-2-[2-(dimethylamino)ethyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione, Benzisoquinolinedione, Fa 142, M-Fa 142, Made-Fa 142, NSC 308847, Nafidimide, Nci 308847

Description

Amonafide is a basic fibroblast growth factor (bFGF) cyclic peptide that has been shown to inhibit the proliferation of renal cell cancer cells. It also has anti-cancer properties, including inhibiting the viability of cancer cells and preventing angiogenesis. Amonafide inhibits the mitochondrial membrane potential of both normal and cancer cells, which leads to a decrease in ATP synthesis. Amonafide is chemically stable at high temperatures, making it an ideal candidate for use in hyperproliferative diseases such as cancer.

• Brand: Biosynth

Chemical properties

• Molecular weight: 283.33 g/mol
• Formula: C₁₆H₁₇N₃O₂
• Purity: Min. 95%
• Color/Form: Yellow Powder
• InChI: InChI=1S/C16H17N3O2/c1-18(2)6-7-19-15(20)12-5-3-4-10-8-11(17)9-13(14(10)12)16(19)21/h3-5,8-9H,6-7,17H2,1-2H3
• InChI key: InChIKey=UPALIKSFLSVKIS-UHFFFAOYSA-N
• SMILES: CN(C)CCN1C(=O)c2cccc3cc(N)cc(c23)C1=O