Apicidin
CAS: 183506-66-3
Ref. 3D-FA17952
| 1mg | To inquire | |
| 2mg | To inquire | |
| 5mg | To inquire | |
| 10mg | To inquire | |
| 25mg | To inquire |
Product Information
- Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]Cyclo(8-oxo-L-2-aminodecanoyl-1-metho xy-L-tryptophyl-L-isoleucyl-D-2-piperidinecarbonyl)Apicidin ia
- Cyclo-L-(2-Amino-8-Oxodeacanoyl)-L-(N-Methoxy-Tryptophan)-L-Isoleucyl-D-Pipecolinyl
- Cyclo-[L-(2-Amino-8-Oxodecanoyl)-L-(N-Methoxytryptophan)-L-Isoleucyl-D-Pipecolinyl
- Cyclo[(2S)-2-Amino-8-Oxodecanoyl-1-Methoxy-L-Tryptophyl-L-Isoleucyl-(2R)-2-Piperidinexcarbonyl]
- Apicidin, Fusarium Species
- (3S,6S,9S,15aR)-6-[(1-methoxy-1H-indol-3-yl)methyl]-9-[(1S)-1-methylpropyl]-3-(6-oxooctyl)octahydro-2H-pyrido[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10(3H,12H)-tetrone
Apicidin is a cyclic peptide that is structurally similar to the natural antibiotic apigenin. It has been shown to inhibit cancer cell proliferation and induce apoptosis in vitro. Apicidin has also been shown to be effective against squamous carcinoma, hl-60 cells, and mitochondrial membrane potential, as well as other types of cancer cells in vivo. Apicidin binds to the mitochondrial membrane and inhibits ATP synthesis by blocking the electron transport chain. This causes a decrease in cellular energy production and an increase in intracellular oxidative stress which leads to apoptosis.
Chemical properties
Technical inquiry about: 3D-FA17952 Apicidin
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