2-Amino-3-bromo-5-chloropyrazine
CAS: 76537-18-3
Ref. 3D-FA42372
| 1g | To inquire | ||
| 250mg | To inquire | ||
| 500mg | To inquire |
Product Information
- (3-Bromo-5-chloropyrazin-2-yl)amine
- 2-Pyrazinamine, 3-Bromo-5-Chloro-
- 3-Bromo-5-chloro-2-aminopyrazine
- 3-Bromo-5-chloro-2-pyrazinamine
- 3-Bromo-5-chloropyrazin-2-amine
- Pyrazinamine, 3-bromo-5-chloro-
2-Amino-3-bromo-5-chloropyrazine (2ABPC) is a hydrophobic, nucleophilic, and reactive nitrile that can be used to synthesize pharmaceutically active compounds. It is synthesized by the reaction of 2-aminopyridine with bromochloromethane in the presence of sodium methoxide. The synthesis of 2ABPC is highlighted in the scheme below:
The first step in this process involves the chlorination of 2-aminopyridine to produce 2-(chloromethyl)pyridine. The second step is a regioselective nitration using bromochloromethane in the presence of sodium methoxide to produce 2-(chloromethyl)-5-nitropyridine. Finally, reduction with hydrogen gas and hydrochloric acid produces 2ABPC.
Chemical properties
Technical inquiry about: 3D-FA42372 2-Amino-3-bromo-5-chloropyrazine
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