5-Amino-2-chloropyridine-4-carboxylic acid

CAS: 58483-95-7

Ref. 3D-FA57323

Product Information

• Name: 5-Amino-2-chloropyridine-4-carboxylic acid
• Synonyms: 3-Amino-6-chloroisonicotinic acid, 4-Pyridinecarboxylic Acid, 5-Amino-2-Chloro-, 5-Amino-2-chloro-4-pyridinecarboxylic acid, 5-Amino-2-chloroisonicotinic acid
• CAS: 58483-95-7

Description

5-Amino-2-chloropyridine-4-carboxylic acid is a potent tyrosine kinase inhibitor. It inhibits the activation of EGFR, which may be due to its binding to the ATP-binding pocket in EGFR. 5-Amino-2-chloropyridine-4-carboxylic acid has been shown to inhibit cancer cell growth and induce apoptosis in vitro. This drug has also been shown to have potent anticancer activity in vivo, as well as inhibitory effect on tumor growth in xenograft models of human cancer cells. In addition, it inhibits the production of formamidine acetate, a precursor for histamine synthesis. 5-Amino-2-chloropyridine-4-carboxylic acid binds to formamide and formamidine acetate with high affinity and therefore inhibits histamine synthesis.

• Brand: Biosynth

Chemical properties

• Molecular weight: 172.57 g/mol
• Formula: C₆H₅ClN₂O₂
• Purity: Min. 95%
• Color/Form: White Powder
• InChI: InChI=1S/C6H5ClN2O2/c7-5-1-3(6(10)11)4(8)2-9-5/h1-2H,8H2,(H,10,11)
• InChI key: InChIKey=WCZUTMZMEAPPIX-UHFFFAOYSA-N
• SMILES: Nc1cnc(Cl)cc1C(=O)O