1-Amino-1-cycloheptane carboxylic acid

CAS: 6949-77-5

Ref. 3D-FA59790

Product Information

• Name: 1-Amino-1-cycloheptane carboxylic acid
• Synonyms: 1-Amino-1-Cycloheptanecarboxylic Acid, 1-Amino-cycloheptanecarboxylic acid, 1-Aminocycloheptane-1-Carboxylic Acid, 1-Azaniumylcycloheptane-1-carboxylate, Acide 1-aminocycloheptanecarboxylique, Cycloheptanecarboxylic Acid, 1-Amino-, NSC 22849

Description

1-Amino-1-cycloheptane carboxylic acid is a tetrapeptide and tripeptide that has been shown to inhibit histone deacetylase. This inhibition prevents the removal of acetyl groups from lysine residues in the N-terminal tails of histones, which alters chromatin structure and gene expression. 1-Amino-1-cycloheptane carboxylic acid has been shown to be effective against chronic myeloid leukemia (CML) cells in vitro and in vivo. The CML cells are characterized by a chromosome translocation that creates an oncogenic fusion protein. This fusion protein is the target of 1-amino-1-cycloheptane carboxylic acid, which inhibits its function by blocking the action of two enzymes involved in the synthesis of this protein.

• Brand: Biosynth

Chemical properties

• Molecular weight: 157.21 g/mol
• Formula: C₈H₁₅NO₂
• Purity: Min. 95%
• InChI: InChI=1S/C8H15NO2/c9-8(7(10)11)5-3-1-2-4-6-8/h1-6,9H2,(H,10,11)
• InChI key: InChIKey=IINRZEIPFQHEAP-UHFFFAOYSA-N
• SMILES: NC1(C(=O)O)CCCCCC1