Product Information
- 1-Carbamoylpiperazine
- N-Carbamoylpiperazine
- Nsc 86952
- Piperazine, 1-(aminocarbonyl)-
Piperazine-1-carboxylic acid amide is a non-opioid agent that prevents the release of histamine from mast cells by blocking the IL-2 receptor. It has been shown to be effective in treating chronic cough, and provides relief within hours of treatment. Piperazine-1-carboxylic acid amide also has an inhibitory effect on TRPM8 channels, which are involved in sensing cold temperature and pain sensation. This drug is metabolized through a number of metabolic transformations including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. The pharmacokinetic properties of piperazine-1-carboxylic acid amide have not been fully characterized.
Chemical properties
Technical inquiry about: 3D-FAA62395 Piperazine-1-carboxylic acid amide
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