8-Bromoadenine

CAS: 6974-78-3

Ref. 3D-FB08273

Product Information

• Name: 8-Bromoadenine
• Synonyms: 6-Amino-8-bromopurine
• CAS: 6974-78-3

Description

8-Bromoadenine is a nucleophile that reacts with electrophiles to form adducts. 8-Bromoadenine has been shown to induce DNA strand breaks and oxidative damage in vitro, which may be due to its ability to react with DNA bases and form intramolecular hydrogen bonds. 8-Bromoadenine has also been shown to cause inflammatory bowel disease in mice by increasing the production of proinflammatory cytokines. 8-Bromoadenine induces Toll-like receptor 4 (TLR4) signaling, which leads to enhancement of radiation response. This drug can also be used as the monosodium salt for treating cancer, although it only has a limited number of sequences that can be synthesized.

• Brand: Biosynth

Chemical properties

• Molecular weight: 214.02 g/mol
• Formula: C₅H₄BrN₅
• Purity: Min. 95%
• Color/Form: White Powder
• InChI: InChI=1S/C5H4BrN5/c6-5-10-2-3(7)8-1-9-4(2)11-5/h1H,(H3,7,8,9,10,11)
• InChI key: InChIKey=FVXHPCVBOXMRJP-UHFFFAOYSA-N
• SMILES: Nc1ncnc2nc(Br)[nH]c12