(1R,4S,5S,8R)-8-[(Z)-2-[2,4-Bis(Trifluoromethyl)Phenyl]Ethenyl]-4,8-Dimethyl-6,7-Dioxabicyclo[3.3.1]Nonan-3-One

CAS: 123407-36-3

Ref. 3D-FB103024

Product Information

• Name: (1R,4S,5S,8R)-8-[(Z)-2-[2,4-Bis(Trifluoromethyl)Phenyl]Ethenyl]-4,8-Dimethyl-6,7-Dioxabicyclo[3.3.1]Nonan-3-One
• Synonyms: (1S,4R,5R,8S)-4-((Z)-2,4-Bis(trifluoromethyl)styryl)-4,8-dimethyl-2,3-dioxabicyclo(3.3.1)nonan-7-one, (1S,4R,5R,8S)-4-[(1Z)-2-[2,4-Bis(trifluoromethyl)phenyl]ethenyl]-4,8-dimethyl-2,3-dioxabicyclo[3.3.1]nonan-7-one, (1S,4R,5R,8S)-4-{(Z)-2-[2,4-bis(trifluoromethyl)phenyl]ethenyl}-4,8-dimethyl-2,3-dioxabicyclo[3.3.1]nonan-7-one, 2,3-Dioxabicyclo(3.3.1)nonan-7-one, 4-(2-(2,4-bis(trifluoromethyl)phenyl)ethenyl)-4,8-dimethyl-(1S-(1alpha,4beta(Z),5alpha,8beta))-, 2,3-Dioxabicyclo[3.3.1]nonan-7-one, 4-[(1Z)-2-[2,4-bis(trifluoromethyl)phenyl]ethenyl]-4,8-dimethyl-, (1S,4R,5R,8S)-, 2,3-Dioxabicyclo[3.3.1]nonan-7-one, 4-[2-[2,4-bis(trifluoromethyl)phenyl]ethenyl]-4,8-dimethyl-, [1S-[1α,4β(Z),5α,8β]]-, Arteflene [USAN:INN], Ro 42-1611, Unii-5Pe5Hv9Nf0, Arteflene

Description

(1R,4S,5S,8R)-8-[(Z)-2-[2,4-Bis(Trifluoromethyl)Phenyl]Ethenyl]-4,8-Dimethyl-6,7-Dioxabicyclo[3.3.1]Nonan-3-One is a sesquiterpene lactone that has been shown to have anti-cancer effects against human liver cancer cells. This compound is an analog of the natural product artemisinin and is structurally similar to the herb Artemisia annua L. It has been shown to inhibit cell growth in vitro and in vivo by binding to the p450 enzymes in the liver and blocking their activity. The low bioavailability of this compound is due to its high degree of chemical structure complexity which inhibits absorption from the gut. (1R,4S,5S,8R)-8-[(Z)-2-[2,

• Brand: Biosynth

Chemical properties

• Molecular weight: 408.33 g/mol
• Formula: C₁₉H₁₈F₆O₃
• Purity: Min. 95%