2-Bromo-5-benzoylthiophene

CAS: 31161-46-3

Ref. 3D-FB151313

Product Information

• Name: 2-Bromo-5-benzoylthiophene
• Synonyms: (5-Bromo-2-thienyl)(phenyl)methanone, (5-Bromo-2-thienyl)phenylmethanone, (5-Bromothiophen-2-Yl)(Phenyl)Methanone, (5-Bromothiophen-2-yl)-phenylmethanone, (5-Bromthiophen-2-yl)(phenyl)methanon, 2-Benzoyl-5-bromothiophene, 5-Benzoyl-2-bromothiophene, 5-Bromo-2-thienyl phenyl ketone, Ketone, 5-bromo-2-thienyl phenyl, Methanone, (5-Bromo-2-Thienyl)Phenyl-, NSC 170817
• CAS: 31161-46-3

Description

2-Bromo-5-benzoylthiophene is a brominated hydrophobic compound. It has a catalytic activity and can be used as an antibacterial agent. The 9-oxime of 2-bromo-5-benzoylthiophene is more active than the free drug and is capable of inhibiting the growth of bacteria in vitro. This oxime also has a higher affinity for DNA gyrase and topoisomerase IV than other drugs in this class, which may be due to its hydrophobic nature or bromine substitution. Molecular modeling studies have shown that the chlorine atom in the 9-oxime plays an important role in stabilizing the complex formed with DNA gyrase or topoisomerase IV, which could explain its high activity against these enzymes.

• Brand: Biosynth

Chemical properties

• Molecular weight: 267.14 g/mol
• Formula: C₁₁H₇BrOS
• Purity: Min. 95%
• InChI: InChI=1S/C11H7BrOS/c12-10-7-6-9(14-10)11(13)8-4-2-1-3-5-8/h1-7H
• InChI key: InChIKey=DHPVOIIUHSEYJY-UHFFFAOYSA-N
• SMILES: O=C(c1ccccc1)c1ccc(Br)s1