3,4-Bis(3-indolyl)maleimide

CAS: 119139-23-0

Ref. 3D-FB153761

Product Information

• Name: 3,4-Bis(3-indolyl)maleimide
• Synonyms: 1,3-di(1H-indol-2-yl)-1H-pyrrole-2,5-dione, 1H-Pyrrole-2,5-dione, 3,4-di-1H-indol-3-yl-, 3,4-Bis(1H-indol-3-yl)-2,5-dihydropyrrole-2,5-dione, 3,4-Bis(1H-indol-3-yl)pyrrole-2,5-dione, 3,4-Bis[3-indolyl]-1H-pyrrole-2,5-dione, 3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione, Arcyriarubin A, bisindolylmaleimide IV

Description

3,4-Bis(3-indolyl)maleimide (BIM) is a protein inhibitor that binds to the DNA binding site of protein kinases. BIM inhibits the phosphorylation of protein kinase C and reduces axonal growth in model systems. It has been shown to be effective in inhibiting the activation of toll-like receptors and subsequent inflammatory responses. BIM also inhibits the expression of cytokines, such as IL-6, IL-8, and TNFα, which are involved in inflammation. The drug has been shown to inhibit dna binding activity and whole cell recordings by blocking PKC phosphorylation.

• Brand: Biosynth

Chemical properties

• Molecular weight: 327.34 g/mol
• Formula: C₂₀H₁₃N₃O₂
• Purity: Min. 95%
• InChI: InChI=1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)
• InChI key: InChIKey=DQYBRTASHMYDJG-UHFFFAOYSA-N
• SMILES: O=C1NC(=O)C(c2c[nH]c3ccccc23)=C1c1c[nH]c2ccccc12