6-Benzyloxygramine

CAS: 57765-22-7

Ref. 3D-FB18513

Product Information

• Name: 6-Benzyloxygramine
• Synonyms: (6-Benzyloxyindolyl)-N,N-dimethylmethylamineN,N-dimethyl-6-(phenylmethoxy)-1H-indole-3-methanamineNSC 92545

Description

6-Benzyloxygramine is a thyroxine (T4) metabolite that is formed by the oxidation of 6-hydroxylated T4. It has been shown to inhibit the conversion of T4 to triiodothyronine (T3). This conversion is catalyzed by type I 5'-deiodinase and requires NADPH as cofactor. 6-Benzyloxygramine can also be converted into skatole, which is a foul smelling compound that is excreted in the urine. The biosynthesis of 6-benzyloxygramine occurs in the liver and brain tissues, but it is not known how this compound is generated.

• Brand: Biosynth

Chemical properties

• Molecular weight: 280.36 g/mol
• Formula: C₁₈H₂₀N₂O
• Purity: Min. 95%
• InChI: InChI=1S/C18H20N2O/c1-20(2)12-15-11-19-18-10-16(8-9-17(15)18)21-13-14-6-4-3-5-7-14/h3-11,19H,12-13H2,1-2H3
• InChI key: InChIKey=ARPLSLHBKDIBNO-UHFFFAOYSA-N
• SMILES: CN(C)Cc1c[nH]c2cc(OCc3ccccc3)ccc12