1,4-Bis(maleimido)butane

CAS: 28537-70-4

Ref. 3D-FB18729

Product Information

• Name: 1,4-Bis(maleimido)butane
• Synonyms: 1,1'-(1,4-Butanediyl)bis-1H-pyrrole-2,5-dioneTetramethylenedimaleimideTetramethylenebismaleimide, 1,1′-(1,4-Butanediyl)bis[1H-pyrrole-2,5-dione], 1,4-Bis(maleimide)butane, 1,4-Di(maleimido)butane, 1-[4-(2,5-Dioxopyrrol-1-yl)butyl]pyrrole-2,5-dione, 1H-Pyrrole-2,5-dione, 1,1'- (1,4-butanediyl)bis-, BMB Crosslinker, Maleimide, N,N′-tetramethylenedi-, N,N′-1,4-Butylenebismaleimide, N,N′-Tetramethylenebis[maleimide], N,N′-Tetramethylenedimaleimide, NSC 44747, Tetramethylenebismaleimide, Tetramethylenedimaleimide

Description

1,4-Bis(maleimido)butane is a chemical compound that binds to the active site of ubiquitin ligases and inhibits their activity. It prevents the addition of ubiquitin to other proteins, which may lead to transcriptional regulation. The compound has been shown to inhibit the proliferation of mammalian cells in culture by interfering with mitotic checkpoint control. This agent is also used as a crosslinker in protein-protein interactions studies, where it is covalently attached to one protein and then reacted with a second protein. 1,4-Bis(maleimido)butane has been shown to be pegylated for use as an anti-inflammatory drug.

• Brand: Biosynth

Chemical properties

• Molecular weight: 248.23 g/mol
• Formula: C₁₂H₁₂N₂O₄
• Purity: Min. 95%
• Color/Form: Powder