1,6-Bis(maleimido)hexane

CAS: 4856-87-5

Ref. 3D-FB18731

Product Information

• Name: 1,6-Bis(maleimido)hexane
• Synonyms: 1,1'-(1,6-Hexanediyl)bis-1H-pyrrole-2,5-dione1,6-MaleimidohexaneGMBMI, 1,1'-(Hexane-1,6-diyl)bis-1H-pyrrole-2,5-dione, 1,1′-(1,6-Hexanediyl)bis[1H-pyrrole-2,5-dione], 1,1′-hexane-1,6-diylbis(1H-pyrrole-2,5-dione), 1,6-Bismaleimidehexane, 1,6-Bismaleimidohexane, 1,6-Bmh, 1,6-Dimaleimidohexane, 1,6-Hexamethylenebis[maleimide], 1,6-Hexanediylbismaleimide, 1,6-Maleimidohexane, 1-[6-(2,5-Dioxopyrrol-1-yl)hexyl]pyrrole-2,5-dione, 1H-Pyrrole-2,5-dione, 1,1'-(1,6-hexanediyl)bis-, 1H-Pyrrole-2,5-dione, 1,1'-(1,6-hexanediyl)bis- (9CI), Ai3-51359, BMH Crosslinker, Brn 0253749, Gmbmi, Gp 207R, Hexamethylenediamine bismaleimide, Maleimide, N,N'-hexamethylenedi-, N,N'-Hexamethylenebis(maleimide), N,N'-Hexamethylenedimaleimide, Nsc 12818

Description

1,6-Bis(maleimido)hexane is a cycloaddition process that changes the chemical structure of a molecule by adding a maleimide group to an unsaturated carbon-carbon bond. The biological properties of 1,6-bis(maleimido)hexane have been investigated using FTIR spectroscopy and monoclonal antibody production. 1,6-Bis(maleimido)hexane has shown to be able to induce apoptosis in human serum cells through the mitochondrial membrane potential pathway. 1,6-Bis(maleimido)hexane also induces cell death in tumor cells by inhibiting the epidermal growth factor receptor (EGFR). This drug is metabolized through fatty acid oxidation and site specific metabolism but does not bind to plasma proteins.

• Brand: Biosynth

Chemical properties

• Molecular weight: 276.29 g/mol
• Formula: C₁₄H₁₆N₂O₄
• Purity: Min. 95%
• InChI: InChI=1S/C14H16N2O4/c17-11-5-6-12(18)15(11)9-3-1-2-4-10-16-13(19)7-8-14(16)20/h5-8H,1-4,9-10H2
• InChI key: InChIKey=PYVHLZLQVWXBDZ-UHFFFAOYSA-N
• SMILES: O=C1C=CC(=O)N1CCCCCCN1C(=O)C=CC1=O