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5-Bromo-2,4-diamino-6-hydroxypyrimidine
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5-Bromo-2,4-diamino-6-hydroxypyrimidine

CAS: 6312-72-7

Ref. 3D-FB19067

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Estimated delivery in United States, on Wednesday 22 Jan 2025

Product Information

Name:
5-Bromo-2,4-diamino-6-hydroxypyrimidine
Synonyms:
  • 2,4-Diamino-6-hydroxy-5-bromopyrimidine2,6-Diamino-5-bromo-4(3H)-pyrimidinoneNSC 40393
  • 2,4-Diamino-6-hydroxy-5-bromopyrimidine
  • 2,6-Diamino-5-bromo-1,4-dihydropyrimidin-4-one
  • 2,6-Diamino-5-bromo-1H-pyrimidin-4-one
  • 2,6-Diamino-5-bromo-3,4-dihydropyrimidin-4-one
  • 2,6-Diamino-5-bromo-4(3H)-pyrimidinone
  • 2,6-Diamino-5-bromopyrimidin-4-ol
  • 2,6-diamino-5-bromopyrimidin-4(1H)-one
  • 4(1H)-Pyrimidinone, 2,6-diamino-5-bromo-
  • 4(3H)-Pyrimidinone, 2,6-diamino-5-bromo-
  • See more synonyms
  • 4-Pyrimidinol, 2,6-diamino-5-bromo-
  • 5-Bromo-2,4-diamino-6-pyrimidinol
  • 5-Bromo-2,6-diaminopyrimidin-4(3H)-one
  • NSC 40393
  • NSC 67304
  • NSC 9303
Description:

5-Bromo-2,4-diamino-6-hydroxypyrimidine (5BDAP) is a ribonucleotide and aminoimidazole analog that has been shown to be a potent inhibitor of the enzyme dihydrofolate reductase. 5BDAP is structurally similar to the natural substrate for this enzyme, thymine, and like other analogues, it competes with the natural substrate for binding to the enzyme's active site. 5BDAP binds to the enzyme and blocks its activity, preventing it from reducing dihydrofolic acid into tetrahydrofolic acid. This prevents the production of thymidylate synthase and thymidylate, which are key enzymes in DNA synthesis.

Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
Biosynth
Long term storage:
Notes:

Chemical properties

Molecular weight:
205.01 g/mol
Formula:
C4H5BrN4O
Purity:
Min. 95%
InChI:
InChI=1S/C4H5BrN4O/c5-1-2(6)8-4(7)9-3(1)10/h(H5,6,7,8,9,10)
InChI key:
InChIKey=NLKHCTSHGBTJTH-UHFFFAOYSA-N
SMILES:
Nc1nc(N)c(Br)c(=O)[nH]1
MDL:
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EINECS:
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HS code:

Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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