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N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinoline sulfonamide
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N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinoline sulfonamide

CAS: 127243-85-0

Ref. 3D-FB19217

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Estimated delivery in United States, on Thursday 16 Jan 2025

Product Information

Name:
N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinoline sulfonamide
Synonyms:
  • N-[2-[[3-(4-Bromophenyl)-2-propen-1-yl]amino]ethyl]-5-isoquinolinesulfonamideH-89
  • 5-Isoquinolinesulfonamide, N-(2-((3-(4-bromophenyl)-2-propenyl)amino)ethyl)-
  • 5-Isoquinolinesulfonamide, N-[2-[[3-(4-bromophenyl)-2-propen-1-yl]amino]ethyl]-
  • H 89 (pharmaceutical)
  • H-89
  • H-89 Dihydrochloride Hydrate
  • H-89 Hydrochloride
  • H-89 hydrate dihydrochloride
  • H89
  • IQB
  • See more synonyms
  • N-(2-((3-(4-Bromophenyl)-2-propenyl)amino)ehtyl)-5-isoquinolinesulfonamide dihydrochloride
  • N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide
  • N-(2-[P-Bromocinnamylamino]Ethyl)-5-Isoquinolinesulfonamide Hydrochloride
  • N-(2-{[(2E)-3-(4-bromophenyl)prop-2-en-1-yl]amino}ethyl)isoquinoline-5-sulfonamide
  • N-(2-{[(2E)-3-(4-bromophenyl)prop-2-en-1-yl]amino}ethyl)isoquinoline-5-sulfonamide dihydrochloride
  • N-[2-(4-Bromocinnamylamino)Ethyl]-5-Isoquinoline Sulfonamide
  • N-[2-(P-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE dihydrochloride
  • N-[2-(P-Bromocinnamylamino)Ethyl]-5-Isoquinolinesulfonamide 2Hcl
  • N-[2-[P-Bromocinnamylamino]-Ethyl]-5-Isoquinolinesulfonmide
  • N-[2-[[(E)-3-(4-bromophenyl)prop-2-enyl]amino]ethyl]isoquinoline-5-sulfonamide
  • N-[2-[[3-(4-Bromophenyl)-2-propen-1-yl]amino]ethyl]-5-isoquinolinesulfonamide
  • Protein kinase inhibitor H89
Description:

N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinoline sulfonamide (BQCA) is a potent inhibitor of protein kinase C. It has been shown to inhibit the activation of Ca2+/calmodulin-dependent protein kinase II in rat hippocampal neurons and to inhibit Ca2+/calmodulin-dependent protein kinase IV in bovine brain. BQCA blocks the phosphorylation of epidermal growth factor receptor and inhibits its downstream signaling pathways, leading to neuronal death. This drug has also been shown to inhibit the activity of other serine/threonine kinases, such as PKC, PKD, Raf1, MEK1, MEK2, and p38 MAPK.

Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
Biosynth
Long term storage:
Notes:

Chemical properties

Molecular weight:
446.36 g/mol
Formula:
C20H20BrN3O2S
Purity:
Min. 95%
InChI:
InChI=1S/C20H20BrN3O2S/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20/h1-10,12,15,22,24H,11,13-14H2/b3-2+
InChI key:
InChIKey=ZKZXNDJNWUTGDK-NSCUHMNNSA-N
SMILES:
O=S(=O)(NCCNC/C=C/c1ccc(Br)cc1)c1cccc2cnccc12
MDL:
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Hazard Info

UN Number:
EQ:
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H Statements:
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Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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