L-Buthionine-(S,R)-sulfoximine

CAS: 83730-53-4

Ref. 3D-FB19391

Product Information

• Name: L-Buthionine-(S,R)-sulfoximine
• Synonyms: (2S)-2-Amino-4-(S-butylsulfonimidoyl)butanoic acidL-Buthionine sulfoximineNSC 326231, L-Buthionine-S,R-sulfoximine, NSC 326231, Butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-, (2S)-, L-Buthionine sulfoximine, (2S)-2-Amino-4-(S-butylsulfonimidoyl)butanoic acid

Description

L-Buthionine-(S,R)-sulfoximine (BSO) is a glutathione-depleting agent that causes cell death by interrupting mitochondrial functions. BSO has been shown to be reactive with covalent linkages in polymer compositions and enzyme activities, which results in the inhibition of human osteosarcoma cells. It also has pro-apoptotic properties that have been demonstrated using multivariate logistic regression on taxol toxicity studies. Resistance to BSO is rare, but has been observed in breast cancer cells. The synergistic effect of BSO and other drugs, such as chemotherapeutic agents, is not well understood.

• Brand: Biosynth

Chemical properties

• Molecular weight: 222.31 g/mol
• Formula: C₈H₁₈N₂O₃S
• Purity: Min. 97 Area-%
• Color/Form: White Powder
• InChI: InChI=1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)/t7-,14?/m0/s1
• InChI key: InChIKey=KJQFBVYMGADDTQ-CVSPRKDYSA-N
• SMILES: CCCCS(=N)(=O)CC[C@H](N)C(=O)O