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2-Butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
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2-Butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

CAS: 141645-16-1

Ref. 3D-FB33882

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Estimated delivery in United States, on Thursday 23 Jan 2025

Product Information

Name:
2-Butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
Synonyms:
  • (2-Butyl-5-nitro-1-benzofuran-3-yl)(4-hydroxyphenyl)methanone
  • (2-Butyl-5-nitro-3-benzofuranyl)(4-hydroxyphenyl)methanone
  • (2-Butyl-5-nitrobenzo[b]furan-3-yl)(4-hydroxyphenyl)methanone
  • (2-Butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone
  • 2-(N-Butyl)-3-(4-Hydroxybenzoyl)-5-Nitrobenzofuran
  • Dron-5
  • Dronedarone Intermediate 3
  • Methanone, (2-Butyl-5-Nitro-3-Benzofuranyl)(4-Hydroxyphenyl)-
Description:

2-Butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran (2BA) is an arrhythmic agent that is used to treat atrial fibrillation. 2BA is a Friedel-Crafts acylation product of benzene and methyl ester, which has a high yield. It is a prodrug that is hydrolyzed by esterases to dronedarone, its active form. This drug has been shown to be effective in controlling fibrillation in both animal models and human patients. 2BA binds to the chloride channel on cardiac muscle cells, which leads to the production of hyperpolarizing currents and prevents the generation of action potentials, thereby preventing fibrillation. The methyl group on 2BA also makes it more controllable than other antiarrhythmics.
2BA has been shown to be effective against arrhythmias without causing cardiotoxicity similar to those seen

Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
Biosynth
Long term storage:
Notes:

Chemical properties

Molecular weight:
339.34 g/mol
Formula:
C19H17NO5
Purity:
Min. 95%
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Hazard Info

UN Number:
EQ:
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Forbidden to fly:
Hazard Info:
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