Boc-N-methyl-D-leucine
CAS: 89536-84-5
Ref. 3D-FB47463
2g | Discontinued | ||
5g | Discontinued | ||
10g | Discontinued | ||
25g | Discontinued | ||
50g | Discontinued |
Product Information
- Boc-N-Me-D-Leu-OH
- N-(tert-Butyloxycarbonyl)-N-methyl-D-leucine
- N-(tert-butoxycarbonyl)-N-methyl-D-leucine
- Boc-Nalpha-methyl-D-leucine
Boc-N-methyl-D-leucine is a macrocyclic peptide that has been shown to bind to the active site of a protein called D-alanyl-D-alanine ligase. The binding of this drug to the enzyme prevents the formation of an ATP molecule, which is required for the catalysis of peptide bond formation. Boc-N-methyl-D-leucine also mimics vancomycin, which is an antibiotic that binds to D-alanyl-D-alanine ligase and inhibits its activity. This drug has been shown to inhibit bacterial growth in vitro and in vivo at micromolar concentrations.