5-Bromo-7-methyl-1H-indole-2,3-dione

CAS: 77395-10-9

Ref. 3D-FB70055

Product Information

• Name: 5-Bromo-7-methyl-1H-indole-2,3-dione
• Synonyms: Isatin,5-bromo-7-methyl- (2CI)

Description

5-Bromo-7-methyl-1H-indole-2,3-dione is a lead compound that inhibits the inosine monophosphate (IMP) deaminase enzyme. This compound is an inhibitor of the IMP deaminase enzyme and has been shown to reduce viral load in HIV patients. 5-Bromo-7-methyl-1H-indole-2,3-dione has been studied as a potential treatment for other diseases such as mycophenolic acid renal toxicity and inflammatory bowel disease. This molecule is a regiospecific inhibitor of the IMPDE4 protein with IC50 values of 0.5 μM and 2 μM for the wild type and mutant forms respectively.

• Brand: Biosynth

Chemical properties

• Molecular weight: 240.05 g/mol
• Formula: C₉H₆BrNO₂
• Purity: Min. 95%
• Color/Form: Orange Powder
• InChI: InChI=1S/C9H6BrNO2/c1-4-2-5(10)3-6-7(4)11-9(13)8(6)12/h2-3H,1H3,(H,11,12,13)
• InChI key: InChIKey=NPRAKNSGKOICIE-UHFFFAOYSA-N
• SMILES: Cc1cc(Br)cc2c1NC(=O)C2=O