4-[4-Chloro-5-(3-Fluoro-4-Methoxyphenyl)-1H-Imidazol-1-Yl]Benzenesulfonamide

CAS: 265114-23-6

Ref. 3D-FC100025

Product Information

• Name: 4-[4-Chloro-5-(3-Fluoro-4-Methoxyphenyl)-1H-Imidazol-1-Yl]Benzenesulfonamide
• Synonyms: 4-[4-Chloro-5-(3-fluoro-4-methoxyphenyl)imidazol-1-yl]benzenesulfonamide, Benzenesulfonamide, 4-[4-chloro-5-(3-fluoro-4-methoxyphenyl)-1H-imidazol-1-yl]-, Cimalgex, Cimicoxib, Ur-8880

Description

4-[4-Chloro-5-(3-Fluoro-4-Methoxyphenyl)-1H-Imidazol-1-Yl]Benzenesulfonamide (FLU) is a nonsteroidal anti-inflammatory drug that inhibits the COX enzyme. It has been shown to inhibit the production of inflammatory proteins and cytokines, such as IL1B, IL6, IL8, and MCP1. FLU also inhibits the expression of COX2 by blocking nuclear factor kappa B (NFkB), which is an important mediator in inflammation. This compound also prevents activation of effector proteins that are involved in inflammation such as TNFα and LTB4. FLU has been shown to be effective in reducing inflammation in bowel diseases and repairing intestinal mucosa.

• Brand: Biosynth

Chemical properties

• Molecular weight: 381.81 g/mol
• Formula: C₁₆H₁₃ClFN₃O₃S
• Purity: Min. 95%
• InChI: InChI=1S/C16H13ClFN3O3S/c1-24-14-7-2-10(8-13(14)18)15-16(17)20-9-21(15)11-3-5-12(6-4-11)25(19,22)23/h2-9H,1H3,(H2,19,22,23)
• InChI key: InChIKey=KYXDNECMRLFQMZ-UHFFFAOYSA-N
• SMILES: COc1ccc(-c2c(Cl)ncn2-c2ccc(S(N)(=O)=O)cc2)cc1F