(2E)-3-(4-Chlorophenyl)acryloyl chloride

CAS: 95602-71-4

Ref. 3D-FC121521

Product Information

• Name: (2E)-3-(4-Chlorophenyl)acryloyl chloride
• Synonyms: 2-propenoyl chloride, 3-(4-chlorophenyl)-, (2E)-

Description

(2E)-3-(4-Chlorophenyl)acryloyl chloride is a synthetic chemical that inhibits the activity of the enzyme enkephalinase. This compound has been shown to have antinociceptive properties and is used in assays to study the effect of drugs on pain sensation. The irreversible binding of this compound to the μ-opioid receptor leads to inhibition of enkephalinase, which results in reduced levels of enkephalins and increased levels of endorphins. This compound also binds irreversibly to the striatal membrane, leading to an increase in chloride ion influx into cells and subsequent activation of voltage-gated channels. This results in an increase in neurotransmitter release from presynaptic terminals and a reduction in neurotransmitter uptake by postsynaptic receptors, both contributing to its antinociceptive effects. The tail-flick assay is one such assay that has demonstrated dose-dependent effects with this compound.

• Brand: Biosynth

Chemical properties

• Molecular weight: 201.05 g/mol
• Formula: C₉H₆Cl₂O
• Purity: Min. 95%
• InChI: InChI=1S/C9H6Cl2O/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6H/b6-3+
• InChI key: InChIKey=ZFOVCSTVYYYRSU-ZZXKWVIFSA-N
• SMILES: O=C(Cl)/C=C/c1ccc(Cl)cc1