5-Chloroquinazoline-2,4-diamine

CAS: 17511-21-6

Ref. 3D-FC132059

Product Information

• Name: 5-Chloroquinazoline-2,4-diamine
• Synonyms: 2,4-quinazolinediamine, 5-chloro-, 2,4-Quinazolinediamine, 5-chloro-, 5-Chloro-2,4-quinazolinediamine, Brn 0745674

Description

5-Chloroquinazoline-2,4-diamine is an undescribed compound that has been shown to be a potent inhibitor of the replication of the Toxoplasma gondii protozoan parasite. It binds to the acidic cysteine residues in the parasite's DNA and inhibits its replication by binding to the pyrimidine moiety of nucleotide precursors, preventing deoxyribonucleotide synthesis. This compound is orally active and is metabolized into 5-chloroquinazoline-2,4-diamine hydrochloride, which is then excreted in urine. 5-Chloroquinazoline-2,4-diamine has also been shown to inhibit viral replication through its ability to bind nitrite and form diazonium salt with hydrochloric acid.

• Brand: Biosynth

Chemical properties

• Molecular weight: 194.62 g/mol
• Formula: C₈H₇ClN₄
• Purity: Min. 95%
• InChI: InChI=1S/C8H7ClN4/c9-4-2-1-3-5-6(4)7(10)13-8(11)12-5/h1-3H,(H4,10,11,12,13)
• InChI key: InChIKey=VEVDQDKAMWPQSF-UHFFFAOYSA-N
• SMILES: Nc1nc(N)c2c(Cl)cccc2n1