7-Chloro-2-hydroxyquinoline

CAS: 22614-72-8

Ref. 3D-FC152501

Product Information

• Name: 7-Chloro-2-hydroxyquinoline
• Synonyms: 7-Chloro-2-quinolone, 7-Chloro-1H-quinolin-2-one, 7-chloroquinolin-2(1H)-one

Description

7-Chloro-2-hydroxyquinoline is a quinoline derivative that has been modified to inhibit the activity of topoisomerases. It is an antimicrobial agent that is active against Gram-positive bacteria, including Mycobacterium tuberculosis. 7-Chloro-2-hydroxyquinoline has been shown to have proinflammatory cytokine activities and can be used in the treatment of various infectious diseases, such as tuberculosis. This compound also prevents the synthesis of DNA by interacting with the DNA polymerase enzyme. 7-Chloro-2-hydroxyquinoline binds to the ternary complex of DNA gyrase, topoisomerase IV, and ATP and inhibits its activity by blocking enzymatic sites and preventing the release of ADP from ATP.

• Brand: Biosynth

Chemical properties

• Molecular weight: 179.6 g/mol
• Formula: C₉H₆ClNO
• Purity: Min. 95%
• InChI: InChI=1S/C9H6ClNO/c10-7-3-1-6-2-4-9(12)11-8(6)5-7/h1-5H,(H,11,12)
• InChI key: InChIKey=SDRJFDTZVULXDE-UHFFFAOYSA-N
• SMILES: O=c1ccc2ccc(Cl)cc2[nH]1