4-Chlorophenylhydroxylamine

CAS: 823-86-9

Ref. 3D-FC152507

Product Information

• Name: 4-Chlorophenylhydroxylamine
• Synonyms: benzenamine, 4-chloro-N-hydroxy-, Hydroxylamine, N- (p-chlorophenyl)-, 4-Chloro-N-hydroxyaniline

Description

4-Chlorophenylhydroxylamine is a proton-transfer inhibitor that inhibits the enzyme carbonic anhydrase. 4-Chlorophenylhydroxylamine is used as a test compound to determine the activity of carbonic anhydrase and has been shown to be a reversible inhibitor of this enzyme. The chlorophenyl group in 4-chlorophenylhydroxylamine binds to the magnesium ion at the catalytic site, which blocks access by chloride ions, preventing the conversion of CO2 into bicarbonate and water. This reaction mechanism is irreversible. 4-Chlorophenylhydroxylamine has a pH optimum at 7.4 and exhibits concentration dependence for its inhibition rate. It also shows a constant inhibition rate when exposed to varying concentrations of substrate. The use of liquid chromatography with UV detection is an efficient method for measuring 4-chlorophenylhydroxylamine concentrations in vitro.br>br>

• Brand: Biosynth

Chemical properties

• Molecular weight: 143.57 g/mol
• Formula: C₆H₆ClNO
• Purity: Min. 95%
• InChI: InChI=1S/C6H6ClNO/c7-5-1-3-6(8-9)4-2-5/h1-4,8-9H
• InChI key: InChIKey=VVQDMDRAUXFEND-UHFFFAOYSA-N
• SMILES: ONc1ccc(Cl)cc1