6-Cyclopropyl-8-fluoroisoquinolin-1(2H)-one
CAS: 1242156-53-1
Ref. 3D-FC161324
| 5mg | Discontinued | ||
| 10mg | Discontinued | ||
| 25mg | Discontinued | ||
| 50mg | Discontinued | ||
| 100mg | Discontinued |
Product Information
Name:
6-Cyclopropyl-8-fluoroisoquinolin-1(2H)-one
Description:
6-Cyclopropyl-8-fluoroisoquinolin-1(2H)-one is a potent and selective inhibitor of tyrosine kinases. The compound was discovered by screening for inhibitors of the PDGF receptor in a cellular assay. The structure activity relationship analysis revealed that the 6-cyclopropyl group and 8-fluoroisoquinoline moiety are critical for the inhibitory potency and selectivity. In particular, the 8-fluoroisoquinoline moiety is important for binding to the ATP site on PDGFRs, as well as for binding to other tyrosine kinases such as c-Met, c-Kit, cRaf, cSrc, and EGFR. 6-Cyclopropyl-8-fluoroisoquinolin-1(2H)-one has been shown to have potential therapeutic applications in rheumatoid arthritis by inhibiting the production of proinflammatory cytokines in
Notice:
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Brand:
Biosynth
Long term storage:
Notes:
Chemical properties
Molecular weight:
203.21 g/mol
Formula:
C12H10FNO
Purity:
Min. 95%
InChI:
InChI=1S/C12H10FNO/c13-10-6-9(7-1-2-7)5-8-3-4-14-12(15)11(8)10/h3-7H,1-2H2,(H,14,15)
InChI key:
InChIKey=LDOIRSRUYDIUTP-UHFFFAOYSA-N
SMILES:
O=c1[nH]ccc2cc(C3CC3)cc(F)c12
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