Candesartan ethyl ester

CAS: 139481-58-6

Ref. 3D-FC19663

Product Information

• Name: Candesartan ethyl ester
• Synonyms: 2-Ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid ethyl ester, 1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-, ethyl ester, 1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-, ethyl ester, Candesartan Ethyl Ester, Candesartan cilexetil intermediate:ethyl ester C7, Ethyl 2-ethoxy-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylate, Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate

Description

Candesartan is a non-selective angiotensin II receptor antagonist that is used for the treatment of high blood pressure and heart failure. It belongs to a class of drugs called angiotensin II receptor antagonists, which work by blocking the effects of the hormone angiotensin II on blood vessels, thereby reducing blood pressure. Candesartan ethyl ester is a prodrug that is metabolized in vivo to candesartan cilexetil, its active form. Candesartan has shown efficacy in patients with cardiovascular disorders, including hypertension, congestive heart failure, and coronary artery disease. Candesartan also has been shown to be an effective adjunct therapy for diabetic nephropathy.
Candesartan ethyl ester is an amorphous substance that can exist as different polymorphs. The reaction rate of this drug with organic solvents depends on its polymorphic form: when it exists as the α-form (

• Brand: Biosynth

Chemical properties

• Molecular weight: 468.51 g/mol
• Formula: C₂₆H₂₄N₆O₃
• Purity: Min. 95%
• InChI: InChI=1S/C26H24N6O3/c1-3-34-25(33)21-10-7-11-22-23(21)32(26(27-22)35-4-2)16-17-12-14-18(15-13-17)19-8-5-6-9-20(19)24-28-30-31-29-24/h5-15H,3-4,16H2,1-2H3,(H,28,29,30,31)
• InChI key: InChIKey=BCPWNYREAURMOP-UHFFFAOYSA-N
• SMILES: CCOC(=O)c1cccc2nc(OCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12