N-[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]-6-iodoquinazolin-4-amine

CAS: 231278-20-9

Ref. 3D-FC20079

Product Information

• Name: N-[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]-6-iodoquinazolin-4-amine
• Synonyms: N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-iodo-4-quinazolinamine6-Iodo-4-[3-chloro-4-(3-fluorobenzyloxy)anilino]quinazoline, 4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-iodo-, 4-[[3-Chloro-4-(3-fluorobenzyloxy)phenyl]amino]-6-iodoquinazoline, 6-Iodo-(4-(3-Fluorobenzyloxy)-3-Chlorophenyl)-Quinazolin-4Yl)Amine, 6-Iodo-4-[3-chloro-4-(3-fluorobenzyloxy)anilino]quinazoline, Lapatinib's intermediate, N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazoline-4-amine, N-{3-Chloro-4-[(3-fluorophenyl)-methoxy]-phenyl}-6-iodo-4-quinazolinamine, N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-iodo-4-quinazolinamine, N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-iodoquinazolin-4-amine, [3-Chloro-4-(3-fluoro-benzyloxy)-phenyl]-(6-iodo-quinazolin-4-yl)-amine, [3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl](6-iodoquinazolin-4-yl)amine
• CAS: 231278-20-9

Description

N-[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]-6-iodoquinazolin-4-amine is a dihedral compound that has been shown to have antitumor activity. It inhibits the phosphorylation of tyrosine on the epidermal growth factor receptor (EGFR) and the activation of protein kinase B (PKB). The compound also binds to lapatinib, an anti-cancer drug with a similar mechanism of action. In addition, N-[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]-6-iodoquinazolin-4-amine can be made from 2-amino-5-(chloromethyl)-benzoic acid and acetone in a chemically simple process. The chemical properties of this compound are studied using liquid chromatography. This study shows that impurities such as benzene and nitro compounds

• Brand: Biosynth

Chemical properties

• Molecular weight: 505.71 g/mol
• Formula: C₂₁H₁₄ClFIN₃O
• Purity: Min. 95%