Chloromethyl isopropyl carbonate

CAS: 35180-01-9

Ref. 3D-FC20252

Product Information

• Name: Chloromethyl isopropyl carbonate
• Synonyms: Carbonic acid chloromethyl 1-methylethyl ester[(Isopropyloxycarbonyl)oxy]methyl chloride, CMIC,for Tenofovir, Carbonic acid, chloromethyl 1-methylethyl ester, Chloromethyl 1-methylethyl carbonate, Chloromethyl Propan-2-Yl Carbonate, Chloromethyl propyl carbonate, Chloromethyl-2-propyl Carbonate, Isopropoxycarbonyloxymethyl chloride, Isopropyl chloromethyl carbonate, [(Isopropyloxycarbonyl)oxy]methyl chloride, i-Propyl Chloromethyl Carbonate

Description

Chloromethyl isopropyl carbonate (CIC) is a prodrug that is converted to disoproxil in the body. It has significant cytotoxicity and antiviral activity against HIV and other viruses, but has not been used clinically due to its chemical instability. CIC can be administered orally as a prodrug, with the active form of CIC being tenofovir disoproxil. Tenofovir disoproxil is metabolized by proximal tubules and has shown efficacy for treating hepatitis B and C. Tenofovir has also been shown to decrease the incidence of renal disease in HIV patients.

• Brand: Biosynth

Chemical properties

• Molecular weight: 152.58 g/mol
• Formula: C₅H₉ClO₃
• Purity: Min. 95%
• Color/Form: Colorless Powder
• InChI: InChI=1S/C5H9ClO3/c1-4(2)9-5(7)8-3-6/h4H,3H2,1-2H3
• InChI key: InChIKey=JHYNXXBAHWPABC-UHFFFAOYSA-N
• SMILES: CC(C)OC(=O)OCCl