Combretastatin A4 phosphate disodium salt

CAS: 168555-66-6

Ref. 3D-FC20546

Product Information

• Name: Combretastatin A4 phosphate disodium salt
• Synonyms: 2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 1-(dihydrogen phosphate) sodium saltCA 4P, 2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol dihydrogen phosphate disodium salt, Ca 4Dp, Ca 4P, Ca4P, CombretastatinA4disodiumphosphate(CA4P), Fosbretabulin disodium, Fosbretabulin disodium salt, Ombretastatin A-4 Phosphate, Disodium Salt, Phenol, 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-, 1-(dihydrogen phosphate), sodium salt (1:2), Phenol, 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-, dihydrogen phosphate, disodium salt, Phenol, 2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethenyl]-, dihydrogen phosphate, disodium salt, (Z)-, Sml1131, disodium 2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl phosphate
• CAS: 168555-66-6

Description

Combretastatin A4 phosphate disodium salt is a potential anticancer agent that has shown to be effective in the treatment of certain cancers, including breast, prostate and lung cancer. It inhibits tumor growth by blocking the activation of toll-like receptor 4 (TLR4), which is involved in inflammation. Combretastatin A4 phosphate disodium salt also inhibits cytosolic Ca2+ release, which may be due to its ability to inhibit phospholipase C activity. This drug has significant cytotoxicity against various tumor cells, with an IC50 value of 0.1 μM. Combretastatin A4 phosphate disodium salt also specifically binds to combretastatin receptors and inhibits cellular physiology such as receptor activity and protein synthesis.

• Brand: Biosynth

Chemical properties

• Molecular weight: 440.29 g/mol
• Formula: C₁₈H₁₉Na₂O₈P
• Purity: Min. 95%