(+/-)-Cromakalim

CAS: 94470-67-4

Ref. 3D-FC20586

Product Information

• Name: (+/-)-Cromakalim
• Synonyms: [+/-]-trans-6-Cyano-3,4-dihydro-2,2-dimethyl-4-[2-oxopyrrolidin-1-yl]-2H-1-benzopyran-3-olBRL 34915(3R,4S)-rel-3,4-dihydro-3-hydro xy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile, (+-)-trans-3-Hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-6-chromancarbonitrile, (3R,4S)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-3,4-dihydro-2H-chromene-6-carbonitrile, (3S,4R)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-3,4-dihydro-2H-chromene-6-carbonitrile, 2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-, (3R,4S)-rel-, 2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-, trans-(+-)-, 3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-3,4-dihydro-2H-chromene-6-carbonitrile, Brl 34915, Cromakalim [INN:BAN], Cromakalime, Cromakalime [French], Cromakalimum, Cromakalimum [Latin], Unii-0G4X367Wa3, rel-(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile

Description

Cromakalim is a potassium channel opener that is used to treat cardiac arrhythmia. It blocks the voltage-gated potassium channels in the heart and relieves symptoms of atrial fibrillation, including papillary muscle spasm and tachycardia. Cromakalim also has been shown to have effects on the central nervous system, where it blocks neuronal death and inhibits brain functions. This drug has bronchoconstrictor properties and can cause cell lysis in some cells. Cromakalim is an inhibitor of phospholipase A2 (PLA2) and cyclooxygenase (COX), which are enzymes that produce inflammatory mediators.

• Brand: Biosynth

Chemical properties

• Molecular weight: 286.33 g/mol
• Formula: C₁₆H₁₈N₂O₃
• Purity: Min. 95%
• SMILES: CC1(C)Oc2ccc(C#N)cc2C(N2CCCC2=O)C1O