Cyclothiazide

CAS: 2259-96-3

Ref. 3D-FC20758

Product Information

• Name: Cyclothiazide
• Synonyms: 3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide6-Chloro-3,4-dihydro-3-(5-no rbornen-2-yl)-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxideAnhydron, 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-3,4-dihydro-, 1,1-dioxide, 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-3-(5-norbornen-2-yl)-, 1,1-dioxide, 3-[(1S,4S)-bicyclo[2.2.1]hept-5-en-2-yl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, 6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide, 6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide, 6-Chloro-3-(5-bicyclo[2.2.1]hept-2-enyl)-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide, 6-Chloro-3-(5-norbornen-2-yl)-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxide, 6-chloro-3,4-dihydro-3-(8,9,10-trinorborn-5-en-2-yl)-2H-1,2,4-benzothiadiazine-7-sulphonamide 1,1-dioxide, Anhydron, Aquirel, Ciclotiazida, Cyclothiazid, Doburil, Fluidil, Lilly 35483, MDi 193, Renazide, Valmiran

Description

Cyclothiazide is a low potency drug that has been shown to have inhibitory properties in experimental models of neuronal death. Cyclothiazide inhibits the activity of Ca2+ channels, which leads to neuronal cell death. It also has inhibitory properties on glutamate metabolism and can be used for the treatment of metabolic disorders such as type 2 diabetes. Cyclothiazide also has an effect on nuclear DNA by inhibiting transcriptional activity and increasing apoptosis in cancer cells, with potential use in the treatment of bowel diseases such as Crohn's disease. Cyclothiazide has been shown to be effective against PCSK9, a protein that promotes cholesterol biosynthesis, and may be useful for the treatment of high cholesterol levels.

• Brand: Biosynth

Chemical properties

• Molecular weight: 389.88 g/mol
• Formula: C₁₄H₁₆ClN₃O₄S₂
• Purity: Min. 95%
• Color/Form: White To Off-White To Yellow Solid
• InChI: InChI=1S/C14H16ClN3O4S2/c15-10-5-11-13(6-12(10)23(16,19)20)24(21,22)18-14(17-11)9-4-7-1-2-8(9)3-7/h1-2,5-9,14,17-18H,3-4H2,(H2,16,19,20)
• InChI key: InChIKey=BOCUKUHCLICSIY-UHFFFAOYSA-N
• SMILES: NS(=O)(=O)c1cc2c(cc1Cl)NC(C1CC3C=CC1C3)NS2(=O)=O