8-chloroquinoline
CAS: 611-33-6
Ref. 3D-FC35037
| 2g | To inquire | ||
| 5g | To inquire | ||
| 10g | To inquire | ||
| 25g | To inquire | ||
| 50g | To inquire |
Product Information
- NSC 56815
- Quinoline, 8-chloro-
8-Chloroquinoline is an organochlorine compound that has anti-malarial, anti-parasitic, and anti-bacterial properties. It binds to the parasite's enzyme hemozoin synthase to inhibit the production of hemozoin. 8-Chloroquinoline also inhibits bacterial growth by binding to the enzyme DNA gyrase and prevents bacterial replication. The binding of 8-chloroquinoline to DNA gyrase inactivates it, thus preventing supercoiling of the bacterial DNA. This causes a structural change in the DNA helix that inhibits transcription and replication. 8-Chloroquinoline has been shown to be effective against Mycobacterium tuberculosis with minimal toxicity for liver cells.
Chemical properties
Technical inquiry about: 3D-FC35037 8-chloroquinoline
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