2-Chloro-5-nitronicotinic acid
CAS: 151322-83-7
Ref. 3D-FC51033
| 1g | To inquire | ||
| 50mg | To inquire | ||
| 100mg | To inquire | ||
| 250mg | To inquire | ||
| 500mg | To inquire |
Product Information
- 2-Chloro-5-nitro-3-pyridinecarboxylic acid
- Ethyl 2-chloro-5-nitronicotinate
- Ethyl 2-Chloro-5-Nitropyridine-3-Carboxylate
2-Chloro-5-nitronicotinic acid is a potent inhibitor of HIV-1 reverse transcriptase. It has been shown to inhibit the transcription of HIV-1 with an IC50 value of 0.3 μM, as well as other retroviruses in vitro. 2-Chloro-5-nitronicotinic acid binds reversibly to the active site of the enzyme and inhibits its activity. The binding site for this drug is located at the Y181C position, which is a mutation that renders the enzyme more sensitive to inhibition by 2-chloro-5 nitronicotinic acid than wild type HIV enzymes.
Chemical properties
Technical inquiry about: 3D-FC51033 2-Chloro-5-nitronicotinic acid
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