4-[(7-Chloroquinolin-4-Yl)Amino]-2-(Diethylaminomethyl)-3,6-Difluorophenol

CAS: 155020-40-9

Ref. 3D-FC99668

Product Information

• Name: 4-[(7-Chloroquinolin-4-Yl)Amino]-2-(Diethylaminomethyl)-3,6-Difluorophenol
• Synonyms: 4-((7-Chloro-4-quinolinyl)amino)-2-((diethylamino)methyl)-3,6-difluorophenol, Phenol, 4-((7-chloro-4-quinolinyl)amino)-2-((diethylamino)methyl)-3,6-difluoro-, 4-[(7-Chloroquinolin-4-Yl)Amino]-2-[(Diethylamino)Methyl]-3,6-Difluorophenol

Description

4-[(7-Chloroquinolin-4-Yl)Amino]-2-(Diethylaminomethyl)-3,6-Difluorophenol (CQA) is a potential antimalarial with a novel mechanism of action that has been shown to be effective in treating both chloroquine and pyrimethamine/sulfadoxine resistant strains of Plasmodium falciparum. CQA inhibits the synthesis of heme, which is necessary for the parasite's survival. The compound binds to the parasite's DNA and inhibits the incorporation of an essential sulphur atom into heme. This leads to inhibition of the parasite's growth and development. CQA also has been shown to inhibit the metabolism of cyclic nucleotides by inhibiting cyclic GMP phosphodiesterase activity in cultured cells.

• Brand: Biosynth

Chemical properties

• Molecular weight: 391.84 g/mol
• Formula: C₂₀H₂₀ClF₂N₃O
• Purity: Min. 95%
• InChI: InChI=1S/C20H20ClF2N3O/c1-3-26(4-2)11-14-19(23)18(10-15(22)20(14)27)25-16-7-8-24-17-9-12(21)5-6-13(16)17/h5-10,27H,3-4,11H2,1-2H3,(H,24,25)
• InChI key: InChIKey=WNWQFAFJVCDDLQ-UHFFFAOYSA-N
• SMILES: CCN(CC)Cc1c(O)c(F)cc(Nc2ccnc3cc(Cl)ccc23)c1F