Methylterephthalonitrile
CAS: 55984-93-5
Ref. 3D-FCA98493
| 1g | Discontinued | ||
| 5g | Discontinued | ||
| 10g | Discontinued | ||
| 25g | Discontinued | ||
| 0.5g | Discontinued | ||
| 100mg | Discontinued | ||
| 500mg | Discontinued |
Product Information
- 2-Methyl-1,4-benzenedicarbonitrile
- 2-Methylbenzene-1,4-Dicarbonitrile
Methylterephthalonitrile is an organometallic compound that inhibits the activity of serine protease enzymes and has been used as a fluorescence probe for studying proteins. The amide group on the nitrogen atom can be converted to an ester, which is more reactive than the amide group. Trifluoromethanesulfonic acid is used to convert the amide group to an ester and this reaction is catalyzed by transfer reactions. Methylterephthalonitrile binds to the active site of serine proteases, preventing them from carrying out their function in biological processes such as inflammation. This drug may have potential for use in inflammatory bowel disease.
Methylterephthalonitrile also reacts with silver ions, forming silver methylterephthalonitrilate complexes. These complexes are potent inhibitors of bacterial growth and have been shown to be effective against strains of Escherichia coli and Pseudomonas aeruginosa
