![1-[[3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl]carbonyl]-3-(piperidin-2-yl)azetidin-3-ol](https://static.cymitquimica.com/products/3D/img/FD102259.png "Click to enlarge")
1-[[3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl]carbonyl]-3-(piperidin-2-yl)azetidin-3-ol
CAS: 934662-91-6
Ref. 3D-FD102259
| 1mg | To inquire | ||
| 5mg | To inquire | ||
| 10mg | To inquire |
Product Information
- Cs-1043
- GDC-0973 racemate||GDC 0973|XL 518|GDC0973|XL518
- Gdc0973
- GDC-0973 racemate
3-Methyl-1-(3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl)azetidin-3-ol is a nucleophilic reagent that reacts with 3-hydroxyazetidine hydrochloride to form a racemic mixture of 3-(piperidin-2-yl)azetidin-3-ol. This reaction can be catalyzed by alkalization. The condensation reaction is the first step in the synthesis of cobimetinib, an antiangiogenic and anticancer drug. Cobimetinib is an orally active small molecule that inhibits angiogenesis by blocking the activity of tyrosine kinase receptors and their downstream signaling pathways. It also has potent anticancer activity against various tumor cells including breast cancer, non-small cell lung cancer, pancreatic cancer, prostate cancer, and colorectal cancer.
Chemical properties
Technical inquiry about: 3D-FD102259 1-[[3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl]carbonyl]-3-(piperidin-2-yl)azetidin-3-ol
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