Product Information
- trans-4-[4-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneacetic acid
AZD 3988 is a new drug candidate that has shown to have anticancer effects. It is an oxadiazole derivative and acts as a prodrug for the formation of cytotoxic metabolites. AZD 3988 has been shown to induce ferroptosis, a type of programmed cell death, in cancer cells. Ferroptosis is characterized by the accumulation of free iron and lipid peroxidation. The endoplasmic reticulum can be targeted by AZD 3988, leading to efficient cell death in vitro. In addition, AZD 3988 may also inhibit cholesterol acyltransferase activity and increase the expression of cholesterol ester transfer protein (CETP). These activities help to reduce serum levels of low-density lipoprotein cholesterol and increase high-density lipoprotein cholesterol levels.
Chemical properties
Technical inquiry about: 3D-FD102952 AZD 3988
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