Digitoxigenin

CAS: 143-62-4

Ref. 3D-FD11670

Product Information

• Name: Digitoxigenin
• Synonyms: 3b,14-Dihydroxy-5b,20(22)-cardenolide,3,14,21-Trihydroxy-20(22)-norcholenic acid lactone5b,20(22)-Cardenolide-3?,14-diol, (+)-Digitoxigenin, (3β,5β)-3,14-Dihydroxycard-20(22)-enolide, 3-Β,14-Dihidroxi-5-Β,14-Β-Card-20(22)-Enolido, 3-Β,14-Dihydroxy-5-Β,14-Β-Card-20(22)-Enolide, 3-β,14-Dihydroxy-5-β,14-β-card-20(22)-enolid, 5β-Card-20(22)-enolide, 3β,14-dihydroxy-, Cerberigenin, Nsc 407806, Δ20:22-3,14,21-Trihydroxynorcholenic acid lactone, Δ^20:22-3,14,21-Trihydroxynorcholenic acid lactone
• CAS: 143-62-4

Description

Digitoxigenin is a natural compound that has been shown to have significant cytotoxicity. Digitoxigenin binds to the drug transporter protein P-gp, which is found in the small intestine and other tissues such as the brain, heart, and lungs. The disulfide bond in digitoxigenin stabilizes the protein-drug complex by preventing it from being degraded by proteases. The digitoxigenin-P-gp complex enters cells through receptor-mediated endocytosis and disrupts cellular function. This compound is toxic to human cells in culture and may be used as a chemotherapeutic agent against cancer.

• Brand: Biosynth

Chemical properties

• Molecular weight: 374.51 g/mol
• Formula: C₂₃H₃₄O₄
• Color/Form: White Powder
• InChI: InChI=1S/C23H34O4/c1-21-8-5-16(24)12-15(21)3-4-19-18(21)6-9-22(2)17(7-10-23(19,22)26)14-11-20(25)27-13-14/h11,15-19,24,26H,3-10,12-13H2,1-2H3/t15-,16+,17-,18+,19-,21+,22-,23+/m1/s1
• InChI key: InChIKey=XZTUSOXSLKTKJQ-CESUGQOBSA-N
• SMILES: C[C@]12CC[C@H](O)C[C@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](C3=CC(=O)OC3)CC[C@]12O