1,3-Dimethyluracil-5-carboxaldehyde
CAS: 4869-46-9
Ref. 3D-FD147434
| 1g | Discontinued | ||
| 2g | Discontinued | ||
| 100mg | Discontinued | ||
| 250mg | Discontinued | ||
| 500mg | Discontinued |
Product Information
Name:
1,3-Dimethyluracil-5-carboxaldehyde
Synonyms:
- 1,3-Dimethyl-5-formyluracil
- 1,3-DiMe-5-FormU
- 5-Pyrimidinecarboxaldehyde, 1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo-
- 1,3-Dimethyl-2,4-Dioxo-1,2,3,4-Tetrahydropyrimidine-5-Carbaldehyde
Description:
1,3-Dimethyluracol-5-carboxaldehyde is an amide of 1,3-dimethyluracil and 5-carboxaldehyde. It has been shown to be an effective radiation sensitizer for the treatment of lymphoblastic leukemia cells in culture. 1,3-Dimethyluracil-5-carboxaldehyde binds to DNA and alters the conformation of the molecule so that it can't be read by the ribosome. This inhibits protein synthesis and causes cell death. The drug also conjugates with DNA to form a covalent bond which causes double strand breaks in the DNA strands. The drug deprotonates at physiological pH levels and reacts with 6-methyluracil to form oxetane derivatives. These compounds are then excreted in urine as quinolizidine alkaloids.
Notice:
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Brand:
Biosynth
Long term storage:
Notes:
Chemical properties
Molecular weight:
168.15 g/mol
Formula:
C7H8N2O3
Purity:
Min. 95%
InChI:
InChI=1S/C7H8N2O3/c1-8-3-5(4-10)6(11)9(2)7(8)12/h3-4H,1-2H3
InChI key:
InChIKey=KGJFRZOATIXYPW-UHFFFAOYSA-N
SMILES:
Cn1cc(C=O)c(=O)n(C)c1=O
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