3,3'-Dihexyloxacarbocyanineiodide

CAS: 53213-82-4

Ref. 3D-FD147721

Product Information

• Name: 3,3'-Dihexyloxacarbocyanineiodide
• Synonyms: 3,3′-Dihexyloxacarbocyanine iodide, 3-Hexyl-2-(3-(3-hexyl-2(3H)-benzoxazolylidene)-1-propenyl)benzoxazolium, 3-Hexyl-2-(3-(3-hexylbenzo[d]oxazol-2(3H)-ylidene)prop-1-en-1-yl)-3H-benzo[d]oxazol-1-ium iodide, Benzoxazolium, 3-hexyl-2-(3-(3-hexyl-2(3H)-benzoxazolylidene)-1-propenyl)-, Benzoxazolium, 3-hexyl-2-[3-(3-hexyl-2(3H)-benzoxazolylidene)-1-propen-1-yl]-, iodide (1:1), Benzoxazolium, 3-hexyl-2-[3-(3-hexyl-2(3H)-benzoxazolylidene)-1-propenyl]-, iodide, D 273, DiOC₆(3), Dioc6, Nk 2280, benzoxazolium, 3-hexyl-2-[3-(3-hexyl-2(3H)-benzoxazolylidene)-1-propen-1-yl]-, DiOC6(3), 3-Hexyl-2-[3-(3-hexyl-1,3-benzoxazol-2(3H)-ylidene)prop-1-en-1-yl]-1,3-benzoxazol-3-ium iodide

Description

3,3'-Dihexyloxacarbocyanineiodide is a chemical inhibitor of apoptosis. It binds to the mitochondrial membrane and blocks the release of cytochrome c from mitochondria into the cytosol, which prevents activation of caspase-9 and -3. The inhibition of these enzymes leads to decreased production of reactive oxygen species (ROS) and protein oxidation, which induces apoptosis. 3,3'-Dihexyloxacarbocyanineiodide has been shown to have an inhibitory effect on proliferation in human squamous cell carcinoma cells. It also inhibits DNA synthesis in hl-60 cells by binding to nuclear DNA. 3,3'-Dihexyloxacarbocyanineiodide also binds to Toll-like receptor 4 (TLR4), which is expressed at high levels in certain cancerous cells such as HL60 cells.

• Brand: Biosynth

Chemical properties

• Molecular weight: 572.52 g/mol
• Formula: C₂₉H₃₇IN₂O₂
• Purity: Min. 95%