Di-tert-butylphosphite
CAS: 13086-84-5
Ref. 3D-FD153843
| 2g | 72.00 € | ||
| 10g | 177.00 € | ||
| 50g | 571.00 € | ||
| 100g | 961.00 € | ||
| 250g | 2,046.00 € |
Product Information
- 2-Methyl-2-[(2-methylpropan-2-yl)oxyphosphonoyloxy]propane
- Di-Tert-Butoxy(Oxo)Phosphonium
- Di-Tert-Butyl Hydrogen Phosphite
- Di-Tert-Butyl Phosphonate
- Phosphonic acid, bis(1,1-dimethylethyl) ester
- Phosphonic acid, di-tert-butyl ester
- Phosphorous acid di-tert-butyl ester
- tert-Butyl phosphite ((C<sub>4</sub>H<sub>9</sub>O)<sub>2</sub>P(OH))
- tert-Butyl phosphonate ((C<sub>4</sub>H<sub>9</sub>O)<sub>2</sub>PH(O))
Di-tert-butylphosphite is a phosphatase inhibitor that is used as a synthetic target in drug discovery. Di-tert-butylphosphite binds to the active site of phosphatases and prevents them from hydrolyzing the phosphate group from their substrates. This leads to an accumulation of the substrate and a decrease in enzymes, which inhibits protein synthesis. The sequence specificity of di-tert-butylphosphite has been shown by its affinity for tripeptides with hydrophobic amino acids at position P1 and P3. Di-tert-butylphosphite has been shown to inhibit cancer cell growth in vitro by binding to DNA and inhibiting RNA synthesis. It also inhibits farnesyl diphosphate synthase, which synthesizes the precursor for cholesterol biosynthesis, leading to decreased levels of cholesterol and reduced cell proliferation.
Chemical properties
Technical inquiry about: 3D-FD153843 Di-tert-butylphosphite
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