![1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one](https://static.cymitquimica.com/products/3D/img/FD172815.png "Click to enlarge")
1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one
CAS: 153587-01-0
Ref. 3D-FD172815
| 1mg | Discontinued | ||
| 2mg | Discontinued | ||
| 5mg | Discontinued | ||
| 10mg | Discontinued | ||
| 25mg | Discontinued |
Product Information
Name:
1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one
Synonyms:
- 1-(2'-Hydroxy-5'-trifluoromethylphenyl)-5-trifluoromethyl-2(3H)-benzimidazolone
- 1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-1,3-dihydro-2H-benzimidazol-2-one
- 2H-Benzimidazol-2-one, 1,3-dihydro-1-(2-hydroxy-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-
- NS 1619
- NS-1619
Description:
1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one is a compound that inhibits mitochondrial respiratory complex I. It binds to the mitochondrial ATP synthase and prevents the synthesis of adenosine triphosphate (ATP), which is essential for the function of the mitochondria. This drug has been shown to inhibit microglia, which are cells in the central nervous system that play a role in inflammatory response. The drug also has been shown to induce reactive oxygen species production, as well as mitochondrial membrane depolarization and hyperpolarization in SKN-SH cells.
Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
Biosynth
Long term storage:
Notes:
Chemical properties
Molecular weight:
362.23 g/mol
Formula:
C15H8F6N2O2
Purity:
Min. 95%
InChI:
InChI=1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25)
InChI key:
InChIKey=YLFMCMWKHSDUCT-UHFFFAOYSA-N
SMILES:
O=c1[nH]c2cc(C(F)(F)F)ccc2n1-c1cc(C(F)(F)F)ccc1O
MDL:
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