Dehydroemetine

CAS: 4914-30-1

Ref. 3D-FD176775

Product Information

• Name: Dehydroemetine
• Synonyms: (-)-2,3-Dehydroemetine, (11bS)-3-Ethyl-1,6,7,11b-tetrahydro-9,10-dimethoxy-2-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolinyl]methyl]-4H-benzo[a]quinolizine, 2,3-Didehydro-6',7',10,11-tetramethoxyemetan, 2,3-Didehydroemetine, 2-Dehydroemetine, 3-Ethyl-9,10-dimethoxy-1,6,7,11b-tetrahydro-2-((1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolyl)methyl)-4H-benzo(a)quinolizine, 4H-Benzo[a]quinolizine, 3-ethyl-1,6,7,11b-tetrahydro-9,10-dimethoxy-2-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolinyl]methyl]-, (11bS)-, 6',7',10,11-Tetramethoxy-2,3-Didehydroemetan, Bt 436, Ccris 4110, Dehidroemetina, Dehidroemetina [INN-Spanish], Dehydroemetine [INN:BAN:DCF], Dehydroemetinum, Dehydroemetinum [INN-Latin], Emetan, 2,3-didehydro-6',7',10,11-tetramethoxy- (9CI), Emetan, 2,3-didehydro-6′,7′,10,11-tetramethoxy-, Emetine, 2,3-dehydro-, (-)-, Emetine, 2,3-didehydro-, Emetine, 2-dehydro-, Emetine, dehydro-, Mebadin, Nsc 131546, Ro 1-9334, Ro 1-9334/19, Unii-7S79Qt1T91

Description

Dehydroemetine is a chemical compound that is used in the treatment of leukemic mice. It has been shown to have cardiotoxic effects and may cause cardiac arrest in humans. Dehydroemetine inhibits the synthesis of DNA by binding to the enzyme RNA polymerase, which prevents transcription and replication. The drug also has anthelmintic activity against helminths, amoebicidal activity, and genotoxic effects. Dehydroemetine also induces apoptosis through mitochondrial membrane potential disruption and toll-like receptor 4 activation.

• Brand: Biosynth

Chemical properties

• Molecular weight: 478.62 g/mol
• Formula: C₂₉H₃₈N₂O₄
• Purity: Min. 95%