3,6-Difluoropyrazine-2-carboxamide

CAS: 356783-29-4

Ref. 3D-FD29071

Product Information

• Name: 3,6-Difluoropyrazine-2-carboxamide
• Synonyms: 3,6-Difluoro-2-pyrazinecarboxamide, Pyrazinecarboxamide, 3,6-difluoro-, Pyrazinecarboxamide,3,6-difluoro- (9CI), 2-Pyrazinecarboxamide, 3,6-difluoro-

Description

3,6-Difluoropyrazine-2-carboxamide is a pyrazine derivative that is a new antiviral drug. It has been optimized for hydration and crystallization in order to obtain high yields of the desired product. The synthesis of 3,6-difluoropyrazine-2-carboxamide starts with chlorination of 2-chloroquinoline to give 3,6-difluoroquinoline. Reaction with ammonia gas gives 4-(3,6-difluoro)pyridine. Reaction of this compound with sodium methoxide gives the corresponding carboxylic acid. The final step in the synthesis is condensation of the carboxylic acid with ethyl pyruvate to give 3,6-difluoropyrazine-2-carboxamide.

• Brand: Biosynth

Chemical properties

• Molecular weight: 159.09 g/mol
• Formula: C₅H₃F₂N₃O
• Purity: Min. 95%
• InChI: InChI=1S/C5H3F2N3O/c6-2-1-9-4(7)3(10-2)5(8)11/h1H,(H2,8,11)
• InChI key: InChIKey=WIQUNYNMYIJSCV-UHFFFAOYSA-N
• SMILES: NC(=O)c1nc(F)cnc1F