2,6-Dichloro-4-iodopyrimidine
CAS: 98027-84-0
Ref. 3D-FD32638
| 2g | To inquire | ||
| 5g | To inquire | ||
| 10g | To inquire | ||
| 25g | To inquire | ||
| 50g | To inquire |
Product Information
- Pyridine, 2,6-dichloro-4-iodo-
2,6-Dichloro-4-iodopyrimidine is a small molecule with potent anticancer activity. It is one of two compounds that were identified as potential treatments for ceralasertib-resistant pancreatic cancer cells. 2,6-Dichloro-4-iodopyrimidine inhibits the kinase activity of the protein Csk in an ATP competitive manner. This inhibitor has been synthesized by a stepwise process involving nucleophilic substitution and coupling reactions to form 2,6-dichloropyrimidine from 2,4,5-trichloropyrimidine and iodide ion. The product was then reacted with dichloromethyl chloroformate to yield 2,6-dichloro-4-iodopyrimidine following a nucleophilic substitution reaction. Other analogs have been prepared in order to alter the potency or selectivity of this compound for other targets such as tyrosine kinases and protein
Chemical properties
Technical inquiry about: 3D-FD32638 2,6-Dichloro-4-iodopyrimidine
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